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PI: Shaine Morris, MD; Betul Yilmaz, MD | Baylor College of Medicine, Houston, Texas

Specific Aims:

  • To describe a large cohort of fetuses with congenital moderate to severe mitral valve regurgitation, either in isolation or in combination with other left-sided obstructive┬álesions/conditions such as congenital aortic annular hypoplasia or valvar stenosis.
  • To describe longitudinal changes in mitral regurgitation and fetal hemodynamics in fetuses with serial studies.
  • To determine what prenatal echocardiographic features in congenital mitral valve regurgitation are associated with a) fetal survival b) neonatal survival after live birth (survival to 28 days of life) c) fetal or neonatal survival (overall survival to 28 days including fetal death) d) survival to discharge e) overall survival.
  • To describe fetal interventions that have been performed to date in these fetuses and to describe outcomes in this subpopulation.
  • To describe fetal strain values in this population subset of studies for which this is able to be collected and to compare them to reference valuesImproved knowledge of the population and outcomes with mitral valve regurgitation will help 1) aid in prenatal counseling, and 2) guide future management decisions for fetuses diagnosed with mitral valve regurgitation. We propose that identification of this unique cardiovascular finding will allow us to develop novel strategies to improve outcomes for this patient population.